Firefox 20 is now available for download. The emphasis of today’s release is on Firefox’s?private browsing mode, which now allows Firefox desktop users to open a private browsing session without the need to shut down the whole browser, while Firefox for Android users can use per-tab private browsing. Also new in this version is a download manager for the desktop, the ability to customize the shortcuts on the home screen with your favorite sites and support for additional HTML5 and WebRTC features. The new version of Firefox for Android now also supports more devices that use less powerful ARMv6 processors, including the Samsung Galaxy Next, Dart, Pop and Q, as well as the HTC Aria and Legend. The new porn per-tab private browsing mode, Mozilla writes in today’s announcement, lets you “shop for a birthday gift in a private window with your existing browsing session uninterrupted. You can also use a private browsing window to check multiple email accounts simultaneously.” The feature that users will probably notice first, however, is the new download experience. Here is what it looks like: For developers, this new version introduces support for WebRTC’s getUserMedia call, which allows developers to access a user’s camera or microphone (with permission, of course). Firefox 20 also now supports blend modes?for the <canvas> element and a number of <audio> and <video> improvements.
[unable to retrieve full-text content]The authorities said the two Shanghai men, 27 and 87 years old, fell ill after contracting the H7N9 strain in February and died in March.
Genetics Society of America's Genetics journal highlights for April 2013Public release date: 1-Apr-2013 [ | E-mail | Share ]
Contact: Phyllis Edelman pedelman@genetics-gsa.org 301-634-7302 Genetics Society of America
Bethesda, MDApril 1, 2013 Listed below are the selected highlights for the April 2013 issue of the Genetics Society of America's journal, Genetics. The April issue is available online at http://www.genetics.org/content/current. Please credit Genetics, Vol. 193, April 2013, Copyright 2013.
Please feel free to forward to colleagues who may be interested in these articles on a wide array of topics including methods, technology and resources; gene expression; genetics of complex traits; genome integrity and transmission; population and evolutionary genetics; cellular genetics; and, genome system biology.
ISSUE HIGHLIGHTS
Methods, Technology and Resources
1. Marker density and read depth for genotyping populations using genotyping-by-sequencing, pp. 1073-1081
Timothy M. Beissinger, Candice N. Hirsch, Rajandeep S. Sekhon, Jillian M. Foerster, James M. Johnson, German Muttoni, Brieanne Vaillancourt, C. Robin Buell, Shawn M. Kaeppler, and Natalia de Leon
Genotyping-by-sequencing enables rapid and efficient genotyping of any species, but it must be appropriately implemented to provide the desired information. This article describes what constitutes sufficient marker information for a variety of genetic studies, and tells how best to obtain that information with genotyping-by-sequencing.
Gene Expression
2. Novel sexual-cycle-specific gene silencing in Aspergillus nidulans, pp. 1149-1162
Wioletta Czaja, Karen Y. Miller, and Bruce L. Miller
Homology-dependent gene silencing operates in many fungi, plants, and animals. This article reports a novel gene silencing system in the fungus Aspergillus nidulans that is sexual-cycle-specific. Duplication of the matA gene encoding a master regulator of sexual differentiation triggers Mat-induced silencing of mating type function and aborts gametogenesis. Mat-induced silencing offers a valuable insight into genome surveillance in eukaryotes.
Genetics of Complex Traits
3. The protein chaperone HSP90 can facilitate the divergence of gene duplicates, pp. 1269-1277
Jennifer Lachowiec, Tzitziki Lemus, James H. Thomas, Patrick J. M. Murphy, Jennifer L. Nemhauser, and Christine Queitsch
Because protein chaperones facilitate folding and stability of their client proteins, clients may be free to accumulate more mutations than nonclients experiencing similar evolutionary pressures. These investigators found that a plant HSP90 client protein shows relaxed selection and hallmarks of neo- and subfunctionalization compared to its nonclient paralog. In addition, they show that systematically identified yeast HSP90 clients also tend to evolve faster than their nonclient paralogs.
Genome Integrity and Transmission
4. Limited RNA editing in exons of mouse liver and adipose, pp. 1107-1115
Sandrine Lagarrigue, Farhad Hormozdiari, Lisa J. Martin, Frdric Lecerf, Yehudit Hasin, Christoph Rau, Raffi Hagopian, Yu Xiao, Jun Yan, Thomas A. Drake, Anatole Ghazalpour, Eleazar Eskin, and Aldons J. Lusis
How prevalent is RNA editing? Several recent studies of RNA editing of exons in humans and mice reached very different conclusions. This article should quiet the controversy. Employing stringent criteria, the authors identified only 63 examples of editing in liver and 188 in adipose tissue of mice. Their results suggest that exonic RNA editing in these tissues is limited to perhaps a few hundred events.
Population and Evolutionary Genetics
5. Inferring admixture histories of human populations using linkage disequilibrium, pp. 1233-1254
Po-Ru Loh, Mark Lipson, Nick Patterson, Priya Moorjani, Joseph K. Pickrell, David Reich, and Bonnie Berger
Admixture between previously separated populations shapes patterns of genetic diversity. These investigators present new methods for analyzing data from admixed populations and show how statistics based on linkage disequilibrium can be used to construct a robust test for admixture and to infer admixture-related parameters such as dates, mixture proportions, and phylogenetic relationships. These tools are offered in a fast and flexible software packageALDERand applied to human data, yielding new insights into the admixture history of Sardinians, Pygmies, and Japanese.
Population and Evolutionary Genetics
6. Correcting coalescent analyses for panel-based SNP ascertainment, pp. 1185-1196
James R. McGill, Elizabeth A. Walkup, and Mary K. Kuhner
SNP chips only detect previously identified variants. Analyzing them as if they are fully ascertained leads to biased estimates of population size and other parameters; culling low-frequency SNPs makes the bias worse. This article offers corrections allowing accurate estimation of population parameters from panel-based and frequency-culled SNPs, and recommends strategies for SNP-based data collection and analysis.
Cellular Genetics
7. Nonself recognition through intermolecular disulfide bond formation of ribonucleotide reductase in Neurospora, pp. 1175-1183
Robert P. Smith, Kenji Wellman, Leila Haidari, Hirohisa Masuda, and Myron L. Smith
In addition to its task of manufacturing DNA nucleotides, ribonucleotide reductase has a surprising function in Neurospora crassa: nonself recognition. These investigators discovered that the flexible tail of the enzyme irreversibly crosslinks two alternative forms of the enzyme via an unusual disulfide bond. Their observation that different versions of this tail inhibit the growth of cells that carry the other allelic form offers the possibility of developing specific chemotherapeutic drugs using this system as a prototype.
Genome and Systems Biology
8. The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle, pp. 1279-1295
Jagan Srinivasan, Adler R. Dillman, Marissa G. Macchietto, Liisa Heikkinen, Merja Lakso, Kelley M. Fracchia, Igor Antoshechkin, Ali Mortazavi, Garry Wong, and Paul W. Sternberg
This article presents analysis of the draft genome sequence of a free-living nematode. It reveals striking protein family expansions that likely result from selection in a harsh environment with pathogens. For example, expansion of a eukaryotic release factor protein family suggests an ongoing evolutionary arms race with viruses and transposons. The authors describe a resource that will enable experimental analysis of interesting developmental and behavioral features of this worm, such as its gonad development and use of ascaroside social signals.
###
ABOUT GENETICS: Since 1916, Genetics (http://www.genetics.org/) has covered high quality, original research on a range of topics bearing on inheritance, including population and evolutionary genetics, complex traits, developmental and behavioral genetics, cellular genetics, gene expression, genome integrity and transmission, and genome and systems biology. Genetics, a peer-reviewed, peer-edited journal of the Genetics Society of America is one of the world's most cited journals in genetics and heredity.
ABOUT GSA: Founded in 1931, the Genetics Society of America (GSA) is the professional membership organization for scientific researchers, educators, bioengineers, bioinformaticians and others interested in the field of genetics. Its nearly 5,000 members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. GSA is dedicated to promoting research in genetics and to facilitating communication among geneticists worldwide through its conferences, including the biennial conference on Model Organisms to Human Biology, an interdisciplinary meeting on current and cutting edge topics in genetics research, as well as annual and biennial meetings that focus on the genetics of particular organisms, including C. elegans, Drosophila, fungi, mice, yeast, and zebrafish. GSA publishes Genetics, a leading journal in the field and an online, open-access journal, G3: Genes|Genomes|Genetics. For more information about GSA, please visit http://www.genetics-gsa.org. Also follow GSA on Facebook at facebook.com/GeneticsGSA and on Twitter @GeneticsGSA.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Genetics Society of America's Genetics journal highlights for April 2013Public release date: 1-Apr-2013 [ | E-mail | Share ]
Contact: Phyllis Edelman pedelman@genetics-gsa.org 301-634-7302 Genetics Society of America
Bethesda, MDApril 1, 2013 Listed below are the selected highlights for the April 2013 issue of the Genetics Society of America's journal, Genetics. The April issue is available online at http://www.genetics.org/content/current. Please credit Genetics, Vol. 193, April 2013, Copyright 2013.
Please feel free to forward to colleagues who may be interested in these articles on a wide array of topics including methods, technology and resources; gene expression; genetics of complex traits; genome integrity and transmission; population and evolutionary genetics; cellular genetics; and, genome system biology.
ISSUE HIGHLIGHTS
Methods, Technology and Resources
1. Marker density and read depth for genotyping populations using genotyping-by-sequencing, pp. 1073-1081
Timothy M. Beissinger, Candice N. Hirsch, Rajandeep S. Sekhon, Jillian M. Foerster, James M. Johnson, German Muttoni, Brieanne Vaillancourt, C. Robin Buell, Shawn M. Kaeppler, and Natalia de Leon
Genotyping-by-sequencing enables rapid and efficient genotyping of any species, but it must be appropriately implemented to provide the desired information. This article describes what constitutes sufficient marker information for a variety of genetic studies, and tells how best to obtain that information with genotyping-by-sequencing.
Gene Expression
2. Novel sexual-cycle-specific gene silencing in Aspergillus nidulans, pp. 1149-1162
Wioletta Czaja, Karen Y. Miller, and Bruce L. Miller
Homology-dependent gene silencing operates in many fungi, plants, and animals. This article reports a novel gene silencing system in the fungus Aspergillus nidulans that is sexual-cycle-specific. Duplication of the matA gene encoding a master regulator of sexual differentiation triggers Mat-induced silencing of mating type function and aborts gametogenesis. Mat-induced silencing offers a valuable insight into genome surveillance in eukaryotes.
Genetics of Complex Traits
3. The protein chaperone HSP90 can facilitate the divergence of gene duplicates, pp. 1269-1277
Jennifer Lachowiec, Tzitziki Lemus, James H. Thomas, Patrick J. M. Murphy, Jennifer L. Nemhauser, and Christine Queitsch
Because protein chaperones facilitate folding and stability of their client proteins, clients may be free to accumulate more mutations than nonclients experiencing similar evolutionary pressures. These investigators found that a plant HSP90 client protein shows relaxed selection and hallmarks of neo- and subfunctionalization compared to its nonclient paralog. In addition, they show that systematically identified yeast HSP90 clients also tend to evolve faster than their nonclient paralogs.
Genome Integrity and Transmission
4. Limited RNA editing in exons of mouse liver and adipose, pp. 1107-1115
Sandrine Lagarrigue, Farhad Hormozdiari, Lisa J. Martin, Frdric Lecerf, Yehudit Hasin, Christoph Rau, Raffi Hagopian, Yu Xiao, Jun Yan, Thomas A. Drake, Anatole Ghazalpour, Eleazar Eskin, and Aldons J. Lusis
How prevalent is RNA editing? Several recent studies of RNA editing of exons in humans and mice reached very different conclusions. This article should quiet the controversy. Employing stringent criteria, the authors identified only 63 examples of editing in liver and 188 in adipose tissue of mice. Their results suggest that exonic RNA editing in these tissues is limited to perhaps a few hundred events.
Population and Evolutionary Genetics
5. Inferring admixture histories of human populations using linkage disequilibrium, pp. 1233-1254
Po-Ru Loh, Mark Lipson, Nick Patterson, Priya Moorjani, Joseph K. Pickrell, David Reich, and Bonnie Berger
Admixture between previously separated populations shapes patterns of genetic diversity. These investigators present new methods for analyzing data from admixed populations and show how statistics based on linkage disequilibrium can be used to construct a robust test for admixture and to infer admixture-related parameters such as dates, mixture proportions, and phylogenetic relationships. These tools are offered in a fast and flexible software packageALDERand applied to human data, yielding new insights into the admixture history of Sardinians, Pygmies, and Japanese.
Population and Evolutionary Genetics
6. Correcting coalescent analyses for panel-based SNP ascertainment, pp. 1185-1196
James R. McGill, Elizabeth A. Walkup, and Mary K. Kuhner
SNP chips only detect previously identified variants. Analyzing them as if they are fully ascertained leads to biased estimates of population size and other parameters; culling low-frequency SNPs makes the bias worse. This article offers corrections allowing accurate estimation of population parameters from panel-based and frequency-culled SNPs, and recommends strategies for SNP-based data collection and analysis.
Cellular Genetics
7. Nonself recognition through intermolecular disulfide bond formation of ribonucleotide reductase in Neurospora, pp. 1175-1183
Robert P. Smith, Kenji Wellman, Leila Haidari, Hirohisa Masuda, and Myron L. Smith
In addition to its task of manufacturing DNA nucleotides, ribonucleotide reductase has a surprising function in Neurospora crassa: nonself recognition. These investigators discovered that the flexible tail of the enzyme irreversibly crosslinks two alternative forms of the enzyme via an unusual disulfide bond. Their observation that different versions of this tail inhibit the growth of cells that carry the other allelic form offers the possibility of developing specific chemotherapeutic drugs using this system as a prototype.
Genome and Systems Biology
8. The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle, pp. 1279-1295
Jagan Srinivasan, Adler R. Dillman, Marissa G. Macchietto, Liisa Heikkinen, Merja Lakso, Kelley M. Fracchia, Igor Antoshechkin, Ali Mortazavi, Garry Wong, and Paul W. Sternberg
This article presents analysis of the draft genome sequence of a free-living nematode. It reveals striking protein family expansions that likely result from selection in a harsh environment with pathogens. For example, expansion of a eukaryotic release factor protein family suggests an ongoing evolutionary arms race with viruses and transposons. The authors describe a resource that will enable experimental analysis of interesting developmental and behavioral features of this worm, such as its gonad development and use of ascaroside social signals.
###
ABOUT GENETICS: Since 1916, Genetics (http://www.genetics.org/) has covered high quality, original research on a range of topics bearing on inheritance, including population and evolutionary genetics, complex traits, developmental and behavioral genetics, cellular genetics, gene expression, genome integrity and transmission, and genome and systems biology. Genetics, a peer-reviewed, peer-edited journal of the Genetics Society of America is one of the world's most cited journals in genetics and heredity.
ABOUT GSA: Founded in 1931, the Genetics Society of America (GSA) is the professional membership organization for scientific researchers, educators, bioengineers, bioinformaticians and others interested in the field of genetics. Its nearly 5,000 members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. GSA is dedicated to promoting research in genetics and to facilitating communication among geneticists worldwide through its conferences, including the biennial conference on Model Organisms to Human Biology, an interdisciplinary meeting on current and cutting edge topics in genetics research, as well as annual and biennial meetings that focus on the genetics of particular organisms, including C. elegans, Drosophila, fungi, mice, yeast, and zebrafish. GSA publishes Genetics, a leading journal in the field and an online, open-access journal, G3: Genes|Genomes|Genetics. For more information about GSA, please visit http://www.genetics-gsa.org. Also follow GSA on Facebook at facebook.com/GeneticsGSA and on Twitter @GeneticsGSA.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
WASHINGTON (AP) ? The White House said Saturday it is taking seriously new threats by North Korea but also noted Pyongyang's history of "bellicose rhetoric."
North Korea warned Seoul on Saturday that the Korean Peninsula had entered "a state of war." It also threatened to shut down a border factory complex that is the last major symbol of cooperation between the Koreas.
"We've seen reports of a new and unconstructive statement from North Korea. We take these threats seriously and remain in close contact with our South Korean allies," said Caitlin Hayden, a spokeswoman for the White House National Security Council. "But, we would also note that North Korea has a long history of bellicose rhetoric and threats, and today's announcement follows that familiar pattern."
North Korea's threats are seen as part of an effort to provoke the new government in Seoul to change its policies toward Pyongyang, and to win diplomatic talks with Washington that could get it more aid. The moves also are seen as ways to build domestic unity as North Korea's young leader, Kim Jong Un, strengthens his military credentials.
In recent days, the U.S. flew a pair of nuclear-capable B-2 stealth bombers over an uninhabited South Korean island, dropping dummy munitions as part of annual defense drills that North Korea views as rehearsals for an invasion. Defense Secretary Chuck Hagel also announced that the U.S. will fortify its defenses against a potential North Korean missile attack on the U.S. by adding more than a dozen missile interceptors to the 26 already in place at Fort Greely, Alaska.
North Korea said in a statement Saturday that it would deal with South Korea according to "wartime regulations" and would retaliate against any provocations by the U.S. and South Korea without notice.
"Now that the revolutionary armed forces of the DPRK have entered into an actual military action, the inter-Korean relations have naturally entered the state of war," said the statement, which was carried by the official North Korean news agency and referred to the country by its official name, the Democratic People's Republic of Korea.
Provocations "will not be limited to a local war, but develop into an all-out war, a nuclear war," the statement said.
The White House has stressed the U.S. government's capability and willingness to defend itself and its allies and interests in the region, if necessary.
"We remain fully prepared and capable of defending and protecting the United States and our allies," Hayden said.
___
Follow Darlene Superville on Twitter: http://www.twitter.com/dsupervilleap
GALAX, Va. (AP) ? Virginia State Police say three people have been killed and more than 20 are injured following a 75-vehicle pileup on Interstate 77 near the Virginia-North Carolina border.
The Virginia Department of Transportation says traffic is backed up about 8 miles.
State police say a series of wrecks began around 1:15 p.m. Sunday in the southbound lanes in the area of Fancy Gap Mountain in southwest Virginia. There was heavy fog at the time.
State police spokeswoman Corinne Geller says several vehicles caught fire, but the blazed has been put out.
The interstate is closed in both directions. Northbound lanes are closed so emergency vehicles can get to the southbound lanes.
Motorists are being advised to seek alternate routes.
Firefox 20 is now available for download. The emphasis of today’s release is on Firefox’s?private browsing mode, which now allows Firefox desktop users to open a private browsing session without the need to shut down the whole browser, while Firefox for Android users can use per-tab private browsing. Also new in this version is a download manager for the desktop, the ability to customize the shortcuts on the home screen with your favorite sites and support for additional HTML5 and WebRTC features. The new version of Firefox for Android now also supports more devices that use less powerful ARMv6 processors, including the Samsung Galaxy Next, Dart, Pop and Q, as well as the HTC Aria and Legend. The new porn per-tab private browsing mode, Mozilla writes in today’s announcement, lets you “shop for a birthday gift in a private window with your existing browsing session uninterrupted. You can also use a private browsing window to check multiple email accounts simultaneously.” The feature that users will probably notice first, however, is the new download experience. Here is what it looks like: For developers, this new version introduces support for WebRTC’s getUserMedia call, which allows developers to access a user’s camera or microphone (with permission, of course). Firefox 20 also now supports blend modes?for the <canvas> element and a number of <audio> and <video> improvements.
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Public release date: 1-Apr-2013
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